N-Methyl Naltrexone Bromide
- Catalogue No.: IM111133
- CAS No.: 73232-52-7
- Mol. Formula: C₂₁H₂₆BrNO₄
Description
| Catalogue Number | IM111133 |
| CAS No. | 73232-52-7 |
| Chemical Name | N-Methyl Naltrexone Bromide |
| Synonyms | (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium Bromide; Methylnaltrexone; Methylnaltrexone Bromide; N-Cyclopropylmethyl-noroxymorphone Methobromide; N-Methylnaltrexone Bromide; Naltrexone Methyl Bromide; Naltrexone Methobromide; Relistor; MRZ 2663BR; |
| Molecular Formula | C₂₁H₂₆BrNO₄ |
| Molecular Weight | 436.34 |
| Appearance | White to Pale Brown Solid |
| Melting Point | >237°C (dec.) |
| Storage | -20°C, Hygroscopic |
| Solubility | DMSO (Slightly, Sonicated, Heated), Methanol (Slightly, Heated, Sonicated) |
| Stability | Hygroscopic |
| Applications | A metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective u-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate u-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance. |
| Category | Standards; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites; Opiates; Natural Products; |
Note: All Products are stable to be shipped at room temperature, unless otherwise specified.
