tert-Butyl 4-[6-[[6-(1-Butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino]-pyridin-3-yl]-piperazine-1-carboxylate

  • Catalogue No.: IM033878
  • CAS No.: 866084-31-3
  • Mol. Formula: C₃₃H₄₅N₇O₄

설명

Catalogue Number IM033878
CAS No. 866084-31-3
Chemical Name tert-Butyl 4-[6-[[6-(1-Butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino]-pyridin-3-yl]-piperazine-1-carboxylate
Synonyms 4-[6-[[6-(1-Butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carboxylic Acid tert-Butyl Ester
Molecular Formula C₃₃H₄₅N₇O₄
Molecular Weight 603.75
Appearance Light Yellow Solid
Melting Point 189 -191°
Storage 4°C, Inert atmosphere, Light sensitive
Solubility DMSO (Slightly, Heated. Sonicated), Methanol (Slightly, Sonicated)
Stability Light Sensitive
Applications tert-Butyl 4-[6-[[6-(1-Butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino]-pyridin-3-yl]-piperazine-1-carboxylate is an intermediate in the commercial development of palbociclib, a highly selective reversible inhibitor of CDK 4/6 for breast cancer treatment.
Category Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;

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