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Description
| Catalogue Number | IM003960 |
| CAS No. | 201608-14-2 |
| Chemical Name | Ac-DEVD-AFC |
| Synonyms | N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine; |
| Molecular Formula | C30H34F3N5O13 |
| Molecular Weight | 729.61 |
| Applications | Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 (CPP32) and related cysteine proteases, which emits a blue to green shift in fluorescence. It also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10. It is known that Ac-DEVD-AFC has a greater Stokes' shift than Ac-DEVD-AMC once it has been cleaved. Since caspase-3 is an effector caspase, it is involved in the cleavage of many substrates which promote apoptosis. This indicator excites light at 400 nm and emits light at 505 nm. In addition, Ac-DEVD-AFC is modeled after Asp216 on caspase-3, the PARP cleavage site. Ac-DEVD-AFC is an essential indicator used to monitor the cellular effects of caspase-3. |
| Category | Research Tools; Molecular Biology; Fluorescent Reagents; |
Note: All Products are stable to be shipped at room temperature, unless otherwise specified.
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