ZM 447439

Catalogue No.: IM149226
CAS No.: 331771-20-1
Mol. Formula: C₂₉H₃₁N₅O₄

Description

Catalogue Number	IM149226
CAS No.	331771-20-1
Chemical Name	ZM 447439
Synonyms	N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide;
Molecular Formula	C₂₉H₃₁N₅O₄
Molecular Weight	513.59
Appearance	Pale Yellow Solid
Melting Point	>104°C
Storage	4°C
Solubility	DMSO, Methanol
Applications	It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.
Category	Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;

Note: All Products are stable to be shipped at room temperature, unless otherwise specified.