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| Catalogue Number | IM007200 |
| CAS No. | 149690-12-0 |
| Alternate CAS No. | Free base: 752174-62-2 |
| Chemical Name | (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride |
| Synonyms | (αR,γS)-γ-Amino-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride; [S-(R*,S*)]-γ-Amino-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride; Ethyl (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride |
| Molecular Formula | C₂₀H₂₅NO₂ • HCl |
| Molecular Weight | 347.88 + (36.46) |
| Appearance | White to Off-White Solid |
| Melting Point | 155 – 162°C |
| Storage | -20°C, Hygroscopic |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Stability | Hygroscopic |
| Applications | (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases. |
| Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; Phenethylamines/Amphetamines; |
Note: All Products are stable to be shipped at room temperature, unless otherwise specified.
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